3-Bromo-4-(hex-1-en-1-yl)pyridine → 3-Bromo-4-hexylpyridine

HRID 2390115ノート

反応式

HRID 2390115 の反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]=[CH:9][CH2:10][CH2:11][CH2:12][CH3:13]>CCOC(C)=O.[Pt](=O)=O>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

参加物

4

反応物 1

HCID 670080793-Bromo-4-(hex-1-en-1-yl)pyridine2 回

生成物 1

HCID 585218843-Bromo-4-hexylpyridine

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 3-bromo-4-(hex-1-en-1-yl)pyridine (Intermediate 12; 360 mg; 1.50 mmol) and platinum dioxide (34 mg; 0.15 mmol) in EtOAc (35 mL) was hydrogenated at 7 atm for 1 hour in a PARR apparatus. The reaction mixture was filtered, evaporated and purified by flash column chromatography, eluting with cyclohexane containing increasing amounts of EtOAc, affording the title compound as a colorless liquid.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customevaporated
  3. custompurified by flash column chromatography
  4. washeluting with cyclohexane containing
  5. temperatureincreasing amounts of EtOAc

出典と根拠

ORDレコード
ord-62c1d9b9b9674a1fa1e1a583be010cc2
出典データセット
uspto-grants-2012_09
特許番号
US08273769B2

反応ノート

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