Tetrahydrofuran → 2-Bromo-4-(isopropylsulfonyl)-1-methylbenzene

HRID 2390161ノート

反応式

HRID 2390161 の反応式
[Br:1][C:2]1[CH:7]=[C:6](SC(C)C)[CH:5]=[CH:4][C:3]=1[CH3:12].O[O:14][S:15]([O-:17])=O.[K+].[CH2:19]1[CH2:23]OC[CH2:20]1>O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([S:15]([CH:19]([CH3:23])[CH3:20])(=[O:17])=[O:14])[CH:5]=[CH:4][C:3]=1[CH3:12]

参加物

6

反応物 3

HCID 8028TetrahydrofuranHCID 23707502Potassium hydroxy sulfiteHCID 585218832-Bromo-4-(isopropylthio)-1-methylbenzene

生成物 1

HCID 585220592-Bromo-4-(isopropylsulfonyl)-1-methylbenzene収率 92%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A cooled (0° C.) solution of 2-bromo-4-(isopropylthio)-1-methylbenzene (123 mg) in THF (10 ml) was treated with a solution of oxone (580 mg) in water (6 ml). The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and concentrated to give the title compound (120 mg, 92%).

後処理

  1. washwashed with water
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-2cddf8cfcee24c709daf6588306fcb07
出典データセット
uspto-grants-2012_09
特許番号
US08273769B2

反応ノート

読み込み中…