Ethyl Acetate → 2-Ethyl-5-(methylsulfonyl)aniline
反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[CH2:12])=[C:7]([N+:13]([O-])=O)[CH:6]=1)(=[O:4])=[O:3].CCOC(C)=O>CC(O)=O.[Fe]>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][C:7]=1[NH2:13])[CH3:12]参加物
5
反応条件
- 温度
- 60 °C
実験手順
A solution of 4-(methylsulfonyl)-2-nitro-1-vinylbenzene (Intermediate 121; 3.60 g; 15.8 mmol) in AcOH (100 mL) was treated with a solution of iron (15.9 g; 285 mmol) in AcOH (20 ml) and the reaction mixture was stirred at 60° C. for 1 h. EtOAc was added and the solution was filtered, the solvents removed under reduced pressure. The residue was taken up in EtOAc, washed with a sat. NaHCO3 solution in water, then with brine. The organic layer was dried, filtered and concentrated to give the title compound.
後処理
- filtrationthe solution was filtered
- customthe solvents removed under reduced pressure
- washwashed with a sat. NaHCO3 solution in water
- customThe organic layer was dried
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8799b27152d74b098446b61343b8d02b
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273769B2
反応ノート
読み込み中…