N-[3-tert-butyl-2-methoxy-5-(2-methoxypyridin-3-yl)phenyl]-4-nitrobenzamide → 4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxypyridin-3-yl)phenyl]benzamide

HRID 2390821ノート

反応式

HRID 2390821 の反応式
[C:1]([C:5]1[C:6]([O:31][CH3:32])=[C:7]([NH:19][C:20](=[O:30])[C:21]2[CH:26]=[CH:25][C:24]([N+:27]([O-])=O)=[CH:23][CH:22]=2)[CH:8]=[C:9]([C:11]2[C:12]([O:17][CH3:18])=[N:13][CH:14]=[CH:15][CH:16]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>CCOC(C)=O.CO.[Pd]>[NH2:27][C:24]1[CH:25]=[CH:26][C:21]([C:20]([NH:19][C:7]2[CH:8]=[C:9]([C:11]3[C:12]([O:17][CH3:18])=[N:13][CH:14]=[CH:15][CH:16]=3)[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:6]=2[O:31][CH3:32])=[O:30])=[CH:22][CH:23]=1

参加物

4

反応物 1

HCID 67069874N-[3-tert-butyl-2-methoxy-5-(2-methoxypyridin-3-yl)phenyl]-4-nitrobenzamide

生成物 1

HCID 670700384-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxypyridin-3-yl)phenyl]benzamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

step 4—To a solution of 102 (0.36 g, 0.82 mmol) in EtOAc/MeOH (2:1, 15 mL) was added 10% Pd/C (0.035 g). A stream of hydrogen gas was bubbled through the solution for 20 min, and the white solid precipitate that formed was recovered by filtration to afford 4-amino-N-[3-tert-butyl-2-methoxy-5-(2-methoxypyridin-3-yl)phenyl]benzamide (104).

後処理

  1. customA stream of hydrogen gas was bubbled through the solution for 20 min
  2. customthe white solid precipitate that formed
  3. filtrationwas recovered by filtration

出典と根拠

ORDレコード
ord-60a835d39838461a8ac2700fbb7d9f6a
出典データセット
uspto-grants-2012_09
特許番号
US08273773B2

反応ノート

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