N-bromobutanimide → (2-Bromo-4-tert-butyl-5-methoxy-phenyl)-methanol

HRID 2390861ノート

反応式

HRID 2390861 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][OH:12])=[CH:7][C:6]=1[O:13][CH3:14])([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:22])C(=O)C1>C(Cl)(Cl)(Cl)Cl.OS([O-])=O.[Na+]>[Br:22][C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:6]([O:13][CH3:14])=[CH:7][C:8]=1[CH2:11][OH:12]

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 534014571206775-43-0

生成物 1

HCID 67070042(2-Bromo-4-tert-butyl-5-methoxy-phenyl)-methanol収率 100%

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 23665763Sodium Bisulfite溶媒

実験手順

step b—To a solution of 345 (2.08 g, 10.70 mmol) in CCl4 (75 mL) was added NBS (2.10 g, 11.80 mmol). The reaction was stirred for 15 min then diluted with a cold 10% aqueous NaHSO3. The reaction mixture was extracted with DCM. The organic extract was washed with brine, dried (MgSO4), filtered and concentrated. The residue was taken up in hexanes (80 mL) and then concentrated to afford 2.9 g (100%) of 344a as a white solid.

後処理

  1. extractionThe reaction mixture was extracted with DCM
  2. extractionThe organic extract
  3. washwas washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-1e744d1e0f6d4be5a7ac2ddaf8c8ce87
出典データセット
uspto-grants-2012_09
特許番号
US08273773B2

反応ノート

読み込み中…