Sodium Hydroxide → HCID 9855628、化合物
反応式
[CH:1]1([NH:4][C:5]2[CH:15]=[CH:14][C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][CH:6]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>CCO>[CH:1]1([NH:4][C:5]2[CH:15]=[CH:14][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)[CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of ethyl 4-(cyclopropylamino)-benzoate (0.188 g, 0.916 mmol, CASRN 112033-48-4), 1 M NaOH (1.832 mL, 1.832 mmol) and EtOH (5 mL) was stirred and heated to 80° C. for 2 h. The EtOH was evaporated and the residue diluted with H2O, adjusted to pH ca. 2 and the resulting precipitate filtered, washed with water and air dried to afford 94 mg of 4-(cyclopropylamino)-benzoic acid (336) as a white powder.
後処理
- customThe EtOH was evaporated
- additionthe residue diluted with H2O
- filtrationthe resulting precipitate filtered
- washwashed with water and air
- customdried
出典と根拠
- ORDレコード
- ord-d7627a052c4549eab4ad78ffc5285dc9
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273773B2
反応ノート
読み込み中…