Sodium Hydroxide → 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 2391171

反応式

HRID 2391171 の反応式
[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2].[OH-].[Na+]>CO>[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 57441049methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate

生成物 1

HCID 574410503-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acid収率 81%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Using methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate (2.59 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (1.94 g, yield 81%) was obtained.

出典と根拠

ORDレコード
ord-d06845afec754edbb2aa969379e122bc
出典データセット
uspto-grants-2012_09
特許番号
US08273741B2

関連ノート

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