4-(Trifluoromethyl)phenol → 2-Hydroxy-5-trifluoromethylbenzaldehyde

反応式

[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[C:12](OCC)(=[O:14])C.CCCCCC>>[OH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:8][C:7]=1[CH:12]=[O:14]

参加物

反応物 2

HCID 678744-(Trifluoromethyl)phenol

HCID 21226206Ethyl acetate hexane

生成物 1

HCID 155009882-Hydroxy-5-trifluoromethylbenzaldehyde収率 34%

実験手順

Following the general procedure and FCC purification with 30% ethyl acetate-hexane, 4-trifluoromethyl phenol (10.0 g, 61.7 mmol) gave 2-hydroxy-5-trifluoromethyl-benzaldehyde 27 (3.9 g, 34%) as a pink solid.

出典と根拠

ORDレコード: ord-28e0930bac704493b0adc4c206e0474c
出典データセット: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06855695B2

反応ノート

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