Sodium Hydroxide → 3-(1-cyanocyclopropyl)-N-(3-{[2-(glycoloylamino)imidazo[1,2-b]pyridazin-6-yl]oxy}phenyl)benzamide

HRID 2391524ノート

反応式

HRID 2391524 の反応式
C([O:4][CH2:5][C:6]([NH:8][C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([NH:24][C:25](=[O:37])[C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]5([C:35]#[N:36])[CH2:34][CH2:33]5)[CH:27]=4)[CH:19]=3)=[N:13][N:12]2[CH:38]=1)=[O:7])(=O)C.[OH-].[Na+]>CO>[C:35]([C:32]1([C:28]2[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=2)[C:25]([NH:24][C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([O:17][C:14]3[CH:15]=[CH:16][C:11]4[N:12]([CH:38]=[C:9]([NH:8][C:6](=[O:7])[CH2:5][OH:4])[N:10]=4)[N:13]=3)[CH:19]=2)=[O:37])[CH2:34][CH2:33]1)#[N:36]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 575057512-{[6-(3-{[3-(1-Cyanocyclopropyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazin-2-yl]amino}-2-oxoethyl acetate

生成物 1

HCID 575057523-(1-cyanocyclopropyl)-N-(3-{[2-(glycoloylamino)imidazo[1,2-b]pyridazin-6-yl]oxy}phenyl)benzamide収率 50%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Using 2-{[6-(3-{[3-(1-cyanocyclopropyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazin-2-yl]amino}-2-oxoethyl acetate (130 mg, 0.254 mmol), 1N aqueous sodium hydroxide solution (1.5 mL) and methanol (3 mL) as starting materials and in the same manner as in Example 396, the title compound (59 mg, 50%) was obtained as a pale-yellow powder.

出典と根拠

ORDレコード
ord-2a995612ef7148edbf9177a28e616fcd
出典データセット
uspto-grants-2012_09
特許番号
US08273741B2

反応ノート

読み込み中…