methyl 4-(4-ethenyl-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate → HCID 57826509、化合物
反応式
[CH:1]([C:3]1[CH:4]=[N:5][N:6]([CH3:17])[C:7]=1[C:8]1[CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[S:11][CH:12]=1)=[CH2:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([C:3]1[CH:4]=[N:5][N:6]([CH3:17])[C:7]=1[C:8]1[CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[S:11][CH:12]=1)[CH3:2]参加物
4
実験手順
To a 100 mL round-bottomed flask was added methyl 4-(4-ethenyl-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate and 10% Pd/C in ethyl acetate (15 mL). The mixture was evacuated slightly, refilled with H2 from a balloon and stirred vigorously under an atmosphere of H2 for 1 hour. The reaction was filtered through a 0.2 μm PTFE membrane filter and used without further purification (153 mg, 0.60 mmol, 87%): LC-MS (ES) m/z=251 (M+H)+.
後処理
- customThe mixture was evacuated slightly
- additionrefilled with H2 from a balloon
- filtrationThe reaction was filtered through a 0.2 μm PTFE membrane
- filtrationfilter
- customused without further purification (153 mg, 0.60 mmol, 87%)
出典と根拠
- ORDレコード
- ord-a652815dc3784ac2985bb3c6c928202c
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273782B2
反応ノート
読み込み中…