Diazomethane → Methyl 8-Hydroxyquinoline-2-Carboxylate

HRID 2393091ノート

反応式

HRID 2393091 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=[CH:7]2.[N+](=[CH2:17])=[N-]>O1CCCC1>[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([O:14][CH3:17])=[O:13])[CH:8]=[CH:7]2

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 740798-Hydroxyquinaldic acid

生成物 1

HCID 12336161Methyl 8-Hydroxyquinoline-2-Carboxylate収率 71.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

8-Hydroxyquinoline-2-carboxylic acid (2.08 g) and tetrahydrofuran (200 ml) were combined and stirred with ice bath cooling. Diazomethane (approx. 16.6 mmol in solution in diethyl ether) was then added and the whole stirred for 1.5 h as it slowly warmed to room temperature. Nitrogen was blown through the reaction mixture to purge any excess diazomethane and the solution was evaporated in vacuo to give the title compound (1.6 g).

後処理

  1. temperaturecooling
  2. stirringthe whole stirred for 1.5 h as it
  3. customto purge any excess diazomethane
  4. customthe solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-4c7b361eae324ebeabfcce85d7c21218
出典データセット
uspto-grants-1998_09
特許番号
US05804588

反応ノート

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