Methyl iodide → Methyl 8-methoxyquinoline-2-carboxylate

HRID 2393092ノート

反応式

HRID 2393092 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([O:14][CH3:15])=[O:13])[CH:8]=[CH:7]2.[C:16](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:16][O:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]([O:14][CH3:15])=[O:13])[CH:8]=[CH:7]2

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 12336161Methyl 8-Hydroxyquinoline-2-Carboxylate

生成物 1

HCID 12336162Methyl 8-methoxyquinoline-2-carboxylate収率 100.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Methyl 8-hydroxyquinoline-2-carboxylate (1.6 g), acetone (15 ml), potassium carbonate (1.3 g) and iodomethane (0.6 ml) were combined and stirred at room temperature for 48 h. The solvents were removed in vacuo and the resulting white residue suspended in water (25 ml) which was extracted with ethyl acetate (3×25 ml). The combined organic layers were dried (magnesium sulphate) and the solvents removed in vacuo to give the title compound as a white solid (1.72 g).

後処理

  1. customThe solvents were removed in vacuo
  2. extractionwas extracted with ethyl acetate (3×25 ml)
  3. dry with materialThe combined organic layers were dried (magnesium sulphate)
  4. customthe solvents removed in vacuo

出典と根拠

ORDレコード
ord-374e71d9df9844cc84c39716c23cd704
出典データセット
uspto-grants-1998_09
特許番号
US05804588

反応ノート

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