Tetrahydrofuran → 2-Quinolinecarboxylic acid, 5-bromo-8-methoxy-

HRID 2393093ノート

反応式

HRID 2393093 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:14]([O:16]C)=[O:15])=[N:7]2.O1CCCC1.O.[OH-].[Li+]>O>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:14]([OH:16])=[O:15])=[N:7]2

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 9900802HCID 9900802、化合物

生成物 1

HCID 99436352-Quinolinecarboxylic acid, 5-bromo-8-methoxy-収率 0.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Methyl 5-bromo-8-methoxyquinoline-2-carboxylate (154 g), tetrahydrofuran (40 ml), water (40 ml) and lithium hydroxide monohydrate (0.436 g) were combined and stirred at room temperature for 1.5 h. The tetrahydrofuran was removed in vacuo and the resulting aqueous mixture was acidified with hydrochloric acid. The resulting white precipitate was collected by filtration and dried in vacuo to give the title compound (1.33 g) as a white solid.

後処理

  1. customThe tetrahydrofuran was removed in vacuo
  2. filtrationThe resulting white precipitate was collected by filtration
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-1c10f43d65074e3585a16ba9b4f4a23f
出典データセット
uspto-grants-1998_09
特許番号
US05804588

反応ノート

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