tert-Butanol → HCID 18979069、化合物

HRID 2393094ノート

反応式

HRID 2393094 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](C(O)=O)=[N:7]2.[C:17]([OH:21])([CH3:20])([CH3:19])[CH3:18].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:29])C=CC=CC=1.C([N:41]([CH2:44]C)CC)C>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([NH:41][C:44]([O:21][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:29])=[N:7]2

参加物

5

反応物 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 99436352-Quinolinecarboxylic acid, 5-bromo-8-methoxy-

生成物 1

HCID 18979069HCID 18979069、化合物

反応条件

温度
80 °C

実験手順

5-Bromo-8-methoxyquinoline-2-carboxylic acid (2 g), t-butanol (25 ml) and triethylamine (1.48 ml) were combined under a nitrogen atmosphere and heated to 80° C. Diphenylphosphorylazide (2.29 ml) was added to the solution and heating was continued for 60 h by which time a white preciptate was present. The reaction mixture was evaporated in vacuo onto silica and purified by flash chromatography to give the title compound (1.21 g) as an off white solid.

後処理

  1. temperatureheating
  2. customThe reaction mixture was evaporated in vacuo onto silica
  3. custompurified by flash chromatography

出典と根拠

ORDレコード
ord-8fd8d820442340eda5fdae2f56b55428
出典データセット
uspto-grants-1998_09
特許番号
US05804588

反応ノート

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