Hydrochloric Acid → HCID 7440508、化合物

HRID 2393101ノート

反応式

HRID 2393101 の反応式
C[O:2][C:3](=[O:27])[C@H:4]([NH:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)(=[O:18])=[O:17])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([S:16]([NH:15][C@H:4]([CH2:5][C:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][CH:7]=2)[C:3]([OH:27])=[O:2])(=[O:17])=[O:18])=[CH:20][CH:21]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 6977080HCID 6977080、化合物

生成物 1

HCID 7440508HCID 7440508、化合物収率 93%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 1.3 mmol of 2(R)-[(4-methoxybenzenesulfonyl)amino]-3-(3-indolyl)-propanoic acid methyl ester suspended in 15 mL of ethanol is added 5 mL of aqueous 2.5M sodium hydroxide. The solid suspension dissolved, and is allowed to stir at ambient temperature overnight. The mixture is acidified with aqueous 10% HCl and extracted with ethyl acetate. The organic phase is washed with brine and dried over sodium sulfate. It is concentrated to afford 0.45 g (93%) of a white solid,

後処理

  1. dissolutionThe solid suspension dissolved
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationIt is concentrated

出典と根拠

ORDレコード
ord-16035cd2f2244980a445b7fe7e8c4424
出典データセット
uspto-grants-1998_09
特許番号
US05804593

反応ノート

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