Methyl iodide → HCID 12437725、化合物
反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH3:12])[C:3]=1[C:13]#[N:14].[C:15](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:15][O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH3:12])[C:3]=1[C:13]#[N:14]参加物
5
実験手順
The suspension of 1-hydroxy-3-methyl-2-naphthonitrile (47.23 g), potassium carbonate (71.3 g), iodomethane (100 ml), and DMF (250 ml) was-stirred overnight at ambient temperature. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated. The residue was recrystallized from water/methanol to give the titled compound (50 mg).
後処理
- extractionextracted with ethyl acetate
- washThe organic layer was washed with water
- customdried
- concentrationconcentrated
- customThe residue was recrystallized from water/methanol
出典と根拠
- ORDレコード
- ord-52f3ce113701490fa6ed5d0d74d22784
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05804601
反応ノート
読み込み中…