Sodium Hydroxide → HCID 18975181、化合物
反応式
[Br:1][C:2]1[CH:27]=[CH:26][C:5]2[CH2:6][CH:7]([CH3:25])[N:8](C(OCC)=O)[N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[OH-].[Na+]>CO.O>[Br:1][C:2]1[CH:27]=[CH:26][C:5]2[CH2:6][CH:7]([CH3:25])[NH:8][N:9]=[C:10]([C:11]3[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=3)[C:4]=2[CH:3]=1参加物
5
実験手順
5.20 g (12 mmoles) of 8-bromo-3-ethoxycarbonyl-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 32) are boiled in 104 ml of methanol with 6 ml of 10N sodium hydroxide solution for 2 hours. After cooling, the reaction mixture is diluted with 104 ml of water, and the precipitated crystals are filtered. Thus, 3.99 g (92%) of the title compound are obtained. M.p.: 125°-130° C.