Sodium Hydroxide → 5,5-Dimethoxypentanoic acid

HRID 2393687ノート

反応式

HRID 2393687 の反応式
[CH3:1][O:2][CH:3]([O:11][CH3:12])[CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8].[OH-].[Na+]>CO>[CH3:12][O:11][CH:3]([O:2][CH3:1])[CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 551444Methyl 5,5-dimethoxyvalerate

生成物 1

HCID 118050725,5-Dimethoxypentanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

12 mmoles methyl 5,5-dimethoxypentanoate (Stevens, R. V. et al., J Am Chem Soc (1979) 7054) were dissolved in 20 ml 50% aqueous methanol. 16 mmoles NaOH were added and the mixture was stirred for 2 hr at room temperature. The solvent was then evaporated, the residue layered with 30 ml EtOAc, and the sodium salt neutralized with ice-cold 1N HCl. The aqueous phase was extracted with an additional 20 ml EtOAc, the organic extracts combined and dried over K2CO3. The product was filtered and the solvent evaporated to provide 5,5-dimethoxypentanoic acid.

後処理

  1. customThe solvent was then evaporated
  2. extractionThe aqueous phase was extracted with an additional 20 ml EtOAc
  3. dry with materialdried over K2CO3
  4. filtrationThe product was filtered
  5. customthe solvent evaporated

出典と根拠

ORDレコード
ord-f0f9e1b9ecc04f6c96d765e11669395d
出典データセット
uspto-grants-1998_09
特許番号
US05807979

反応ノート

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