Dimethyl Sulfoxide → HCID 18977180、化合物

HRID 2393736ノート

反応式

HRID 2393736 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][CH:7]=1.[BrH:19].C(O)(=O)C.CS(C)=O.C(OC(C)C)(C)C>C(O)(=O)C>[BrH:19].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:10][CH:11]=1

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 7914Diisopropyl EtherHCID 18977184HCID 18977184、化合物HCID 21893785Acetic Acid Mixture with Hydrobromic Acid

生成物 1

HCID 18977180HCID 18977180、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

In 200 ml of acetic acid was suspended 15.00 g of 6-[4-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one. To the suspension were added 100 ml of a 25% hydrogen bromide-acetic acid solution and then 5.35 g of dimethylsulfoxide, and the mixture was stirred at room temperature for 4.5 hours. 400 ml of isopropyl ether was added to the reaction mixture, and precipitated crystal was collected by filtration and recrystallized from methanol to obtain 18.94 g of 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide.

後処理

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-2261f0e9b39b48fbb6b01f54c9e9a307
出典データセット
uspto-grants-1998_09
特許番号
US05808065

反応ノート

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