Sodium Hydroxide → 2-((Benzyloxy)methyl)-2-methylpropane-1,3-diol

HRID 2393874ノート

反応式

HRID 2393874 の反応式
C(C1[O:9][CH2:8][C:7]([CH2:11][O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([CH3:10])[CH2:6][O:5]1)(C)C.[OH-].[Na+]>CO>[CH2:13]([O:12][CH2:11][C:7]([CH3:10])([CH2:8][OH:9])[CH2:6][OH:5])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 18977333HCID 18977333、化合物

生成物 1

HCID 128574842-((Benzyloxy)methyl)-2-methylpropane-1,3-diol収率 32.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 2 L 3-neck, round-bottom flask, equipped with a reflux condenser, a thermometer, and magnetic stir bar, was charged with 2-isopropyl-5-benzyloxymethyl-5-methyl-1,3-dioxane (48.5 g, 0.183 mol), IN HCI (330 mL), and methanol (600 mL). The mixture was heated to reflux for 3 h, then neutralized with 1N NaOH (~330 mL). The mixture was extracted with CH2Cl2 (600 mL), and the organic layer was separated. The aqueous layer was extracted with 250 mL of CH2 Cl2. The combined organic layer was washed with brine (300 ML), and dried over MgSO4. After removing MgSO4, the solution was concentrated using a rotary evaporator under reduced pressure. The residual oily mixture was purified by column chromatography. It was applied to a column of Silica gel and eluted with 5:1 and 2:3 Hexanes:EtOAc to give 12.5 g of white crystals after removing solvent and drying in vacuo (33% of theory). m.p. (DSC): 54.5° C.; IR (neat): 3280, 2930, 2860, 2840, 1448, 1403, 1354, 1296, 1200, 1150, 1108, 1050, 1021, 990, 962, 892, 727, 688 cm-1 ; 1H NMR (CDC13, 300 Mhz) δ0.84 (s, 3H), 2.92 (s, 2H), 3.45(s, 2H), 3.57 (d, 2H), 3.69 (d, 2H), 4.51 (s, 2H), 7.32 (m, 5H); 13C NMR (CDC13, 75 MHz) δ17.09, 40,77, 67.71, 73.56, 75.49, 127.47, 127.72, 128.43, 137.87.

後処理

  1. customA 2 L 3-neck, round-bottom flask, equipped with a reflux condenser
  2. temperatureThe mixture was heated
  3. temperatureto reflux for 3 h
  4. extractionThe mixture was extracted with CH2Cl2 (600 mL)
  5. customthe organic layer was separated
  6. extractionThe aqueous layer was extracted with 250 mL of CH2 Cl2
  7. washThe combined organic layer was washed with brine (300 ML)
  8. dry with materialdried over MgSO4
  9. customAfter removing MgSO4
  10. concentrationthe solution was concentrated
  11. customa rotary evaporator under reduced pressure
  12. customThe residual oily mixture was purified by column chromatography
  13. washeluted with 5:1 and 2:3 Hexanes

出典と根拠

ORDレコード
ord-e60bd0cf6cf6403983c1b32f84fd8007
出典データセット
uspto-grants-1998_09
特許番号
US05808108

反応ノート

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