(1S,6S)-2,8-Diazabicyclo(4.3.0)nonane → HCID 18665331、化合物

HRID 2394304ノート

反応式

HRID 2394304 の反応式
Cl[C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:16]([OH:18])=[O:17])=[CH:8][N:9]2[CH:13]2[CH2:15][CH2:14]2)=[CH:4][N:3]=1.[C@@H:20]12[CH2:28][NH:27][CH2:26][C@@H:25]1[CH2:24][CH2:23][CH2:22][NH:21]2>CN(C)C=O.C(#N)C>[Cl:12][C:11]1[C:2]([N:27]2[CH2:28][C@@H:20]3[C@@H:25]([CH2:24][CH2:23][CH2:22][NH:21]3)[CH2:26]2)=[N:3][CH:4]=[C:5]2[C:10]=1[N:9]([CH:13]1[CH2:15][CH2:14]1)[CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6]2=[O:19]

参加物

5

反応物 2

HCID 10313138(1S,6S)-2,8-Diazabicyclo(4.3.0)nonaneHCID 189731217,8-Dichloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid

生成物 1

HCID 18665331HCID 18665331、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6342Acetonitrile溶媒

実験手順

200 mg (0.67 mmol) of 7,8-dichloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid are stirred with 190 mg (1.5 mmol) of (1S,6S)-2,8-diazabicyclo[4.3.0]nonane in a mixture of 1.7 ml of dimethylformamide and 1.7 ml of acetonitrile under argon overnight. The precipitate is isolated and washed with acetonitrile. The crude product is purified on silica gel (eluent: dichloromethane/methanol/aqueous ammonia solution 75:20:25).

後処理

  1. customThe precipitate is isolated
  2. washwashed with acetonitrile
  3. customThe crude product is purified on silica gel (eluent: dichloromethane/methanol/aqueous ammonia solution 75:20:25)

出典と根拠

ORDレコード
ord-3937b85528af4856a326fae06cced6c6
出典データセット
uspto-grants-1998_09
特許番号
US05811433

反応ノート

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