Indole-3-Carboxaldehyde → 1-(2-fluorobenzyl)-1H-indole-3-carbaldehyde

反応式

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1.[F:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br>>[F:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1

参加物

反応物 2

HCID 10256Indole-3-Carboxaldehyde

HCID 67968alpha-Bromo-o-fluorotoluene

生成物 1

HCID 7755861-(2-fluorobenzyl)-1H-indole-3-carbaldehyde

実験手順

The same procedures used in Example 1 were repeated except for using 870 mg of indole-3-carbaldehyde and 2-fluorobenzyl bromide in place of the benzyl bromide used in Example 1 to give 1.46 g of 1-(2-fluorobenzyl)indole-3-carbaldehyde as yellowish brown crystals. The yield thereof was found to be 96%.

出典と根拠

ORDレコード: ord-59f9074edc3d4f36921ba4d2d165be41
出典データセット: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05811439

反応ノート

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