Lithium hydroxide, monohydrate → 3-Methoxyindole-6-carboxylic acid
反応式
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=2)[C:6]([O:17][CH3:18])=[CH:5]1)(=O)C.O.[OH-].[Li+]>C1COCC1.O>[CH3:18][O:17][C:6]1[C:7]2[C:12](=[CH:11][C:10]([C:13]([OH:15])=[O:14])=[CH:9][CH:8]=2)[NH:4][CH:5]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
To a solution of methyl 1-acetyl-3-methoxyindole-6-carboxylate (74 mg, 0.3 mmol) in THF (10 ml) and water (2 ml) was added lithium hydroxide hydrate (63 mg, 1.5 mmol). The reaction mixture was warmed to 50° C. and stirred for 3 h. The THF was removed under reduced pressure and the pH of the aqueous phase adjusted to 3. Extraction of the aqueous layer with ethyl acetate, drying and concentration gave the acid (50 mg, 87%);
後処理
- customThe THF was removed under reduced pressure
- extractionExtraction of the aqueous layer with ethyl acetate
- customdrying
- concentrationconcentration
出典と根拠
- ORDレコード
- ord-a114a88948d74f7f916aad27722aebe7
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855715B1
反応ノート
読み込み中…