Ethanol → 4,6-Dibromo-3-fluoro-2-methylbenzoic acid

HRID 2394951ノート

反応式

HRID 2394951 の反応式
[CH3:1][C:2]1[C:11]([F:12])=[C:10]([Br:13])[CH:9]=[C:8]([Br:14])[C:3]=1[C:4]([O:6]C)=[O:5].C(O)C.[OH-].[Na+]>O>[CH3:1][C:2]1[C:11]([F:12])=[C:10]([Br:13])[CH:9]=[C:8]([Br:14])[C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 189744684,6-Dibromo-3-fluoro-2-methyl-benzoic acid methylester

生成物 1

HCID 146512824,6-Dibromo-3-fluoro-2-methylbenzoic acid収率 84.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To methyl 2-methyl-3-fluoro-4,6-dibromobenzoate (75.5 g) are added ethanol (460 ml) and 10% aqueous solution of sodium hydroxide (460 ml) and the mixture is refluxed for 2 hours. After cooling, the reaction mixture is diluted with water and extracted with diethyl ether. The aqueous layer is made acidic with conc. hydrochloric acid and extracted with diethyl ether. The solvent is concentrated to give 2-methyl-3-fluoro-4,6-dibromobenzoic acid (61 g), m.p. 144°-146° C.

後処理

  1. temperaturethe mixture is refluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. extractionextracted with diethyl ether
  5. concentrationThe solvent is concentrated

出典と根拠

ORDレコード
ord-d15f36c42bef46bab5554e397a46ea06
出典データセット
uspto-grants-1998_09
特許番号
US05811576

反応ノート

読み込み中…