4-(3,4-Dichlorophenyl)-3-buten-2-one → HCID 53715145、化合物

HRID 2395597ノート

反応式

HRID 2395597 の反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13](=[O:15])[CH3:14])[CH:7]=[CH:8][C:9]=1[Cl:10]>C(O)C>[Cl:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]([OH:15])[CH3:14])[CH:7]=[CH:8][C:9]=1[Cl:10]

参加物

4

反応物 2

HCID 3265634-(3,4-Dichlorophenyl)-3-buten-2-oneHCID 4311764Sodium borohydride

生成物 1

HCID 53715145HCID 53715145、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.25 g (0.0599 mol) of NaBH4 are added portionwise at room temperature to a suspension of 39.2 g (0.182 mol) of 4-(3,4-dichlorophenyl)-3-buten-2-one in 900 ml of ethanol and the mixture is stirred overnight at room temperature. The mixture is concentrated under vacuum, taken up in water, extracted with methylene chloride, washed with water, dried over sodium sulphate, filtered and evaporated under vacuum. The product obtained is used without subsequent purification in the following stage. Yd.: 35.2 g (89%)

後処理

  1. concentrationThe mixture is concentrated under vacuum
  2. extractionextracted with methylene chloride
  3. washwashed with water
  4. dry with materialdried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated under vacuum
  7. customThe product obtained
  8. customis used without subsequent purification in the following stage

出典と根拠

ORDレコード
ord-cf60c2991c014088927f434838cef0e5
出典データセット
uspto-grants-1996_02
特許番号
US05489592

反応ノート

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