Morpholine → 1-(4-Amidinophenyl)-4-methoxy-3-[4-[2-[(pivaloyloxymethyl)-oxycarbonyl]-ethyl]-phenyl]-3-pyrrolin-2-one
反応式
N1CCOCC1.C(OC([NH:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:26][C:25]([O:27][CH3:28])=[C:24]([C:29]3[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][C:37]([O:39][CH2:40][O:41][C:42](=[O:47])[C:43]([CH3:46])([CH3:45])[CH3:44])=[O:38])=[CH:31][CH:30]=3)[C:23]2=[O:48])=[CH:18][CH:17]=1)=[NH:15])=O)C=C>O1CCCC1>[C:14]([C:16]1[CH:17]=[CH:18][C:19]([N:22]2[CH2:26][C:25]([O:27][CH3:28])=[C:24]([C:29]3[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][C:37]([O:39][CH2:40][O:41][C:42](=[O:47])[C:43]([CH3:44])([CH3:45])[CH3:46])=[O:38])=[CH:31][CH:30]=3)[C:23]2=[O:48])=[CH:20][CH:21]=1)(=[NH:13])[NH2:15]参加物
4
実験手順
Prepared by dropwise addition of 1 equivalent of morpholine to 1-[4-(allyloxycarbonyl-amidino)-phenyl]-4-methoxy-3-[4-[2-[(pivaloyloxymethyl)-oxycarbonyl]ethyl]-phenyl]-3-pyrrolin-2-one and 0.1 equivalents of tetrakis-(triphenyl-phosphine)-palladium(O) in tetrahydrofuran under inert gas followed by 1 hours' stirring at ambient temperature.