Water → HCID 10655699、化合物

HRID 2395945ノート

反応式

HRID 2395945 の反応式
Cl[CH2:2][CH2:3][C:4]([CH3:11])([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[S-:12][C:13]#[N:14].[K+].O>CN(C)C=O>[CH3:10][C:4]([CH3:11])([CH2:3][CH2:2][S:12][C:13]#[N:14])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

5

反応物 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 10797430Ethyl 4-chloro-2,2-dimethylbutanoate

生成物 1

HCID 10655699HCID 10655699、化合物収率 65.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

22.1 g of ethyl 4-chloro-2,2-dimethylbutyrate and 14.5 g of potassium thiocyanate were dissolved in 100 ml of dimethylformamide, followed by stirring at 100° C. for 7 hours. The reaction mixture was added to 500 ml of water and extracted with ethyl ether. After the extract was washed with water and dried over MgSO4, the solvent was distilled off. The residue was distilled under reduced pressure to yield 16.4 g of the title compound in the form of a colorless oily substance.

後処理

  1. extractionextracted with ethyl ether
  2. washAfter the extract was washed with water
  3. dry with materialdried over MgSO4
  4. distillationthe solvent was distilled off
  5. distillationThe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-cfeac0b7b7fb4450924f62dde67ce363
出典データセット
uspto-grants-1996_02
特許番号
US05491145

反応ノート

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