Water → Propanoic acid, 2-[[(4-methoxyphenyl)methyl]thio]-2-methyl-

HRID 2395985ノート

反応式

HRID 2395985 の反応式
[C:1]([C:6]([S:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)([CH3:8])[CH3:7])([O:3]CC)=[O:2].O.O1CCCC1.[OH-].[K+]>C(O)C>[C:1]([C:6]([S:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=1)([CH3:7])[CH3:8])([OH:3])=[O:2]

参加物

6

反応物 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14797Potassium HydroxideHCID 19974022HCID 19974022、化合物

生成物 1

HCID 10421773Propanoic acid, 2-[[(4-methoxyphenyl)methyl]thio]-2-methyl-収率 81.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Dissolve 2-(carboethoxy)-2-(4-methoxybenzylthio)propane (1.05 g, 3.91 mmol)in a mixture of 95% ethanol (18 mL), water (9 mL) and tetrahydrofuran (10 mL). Add potassium hydroxide (1.4 g, 25 mmol) and stir at room temperaturefor 2 hours then at 55° C. for 1 hour. Evaporate the solvent in vacuo and partition between water (50 mL) and ether (50 mL). Acidify to pH1 with concentrated hydrochloric acid and extract into methylene chloride (50 mL). Dry (Na2SO4) and evaporate the solvent in vacuo to give 2-(carboxy)-2-(4-methoxybenzylthio)propane as a tan solid (763 mg).

後処理

  1. customEvaporate the solvent in vacuo
  2. custompartition between water (50 mL) and ether (50 mL)
  3. extractionAcidify to pH1 with concentrated hydrochloric acid and extract into methylene chloride (50 mL)
  4. dry with materialDry (Na2SO4)
  5. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-9d70bcebcb2847dfaec7658445293f50
出典データセット
uspto-grants-1996_02
特許番号
US05491142

反応ノート

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