Acetic Acid → 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine

HRID 23960

反応式

HRID 23960 の反応式
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH:14]([C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[CH2:15].C(O)(=O)C>C(O)C>[C:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:15][CH2:14][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 75024-VinylpyridineHCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 223216311-Boc-4-[2-(4-pyridinyl)ethyl]piperazine収率 46.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-Boc-piperazine (4.0 g, 21.5 mmol), 4-vinylpyridine (2.94 g, 27.9 mmol), and acetic acid (1.29 g, 21.5 mmol) were mixed in ethanol and heated to reflux for 48 h. The mixture was cooled to room temperature and concentrated under vacuum to provide 1-Boc-4-[2-(4-pyridinyl)ethyl]-piperazine (2.9 g, 45%) as an off white solid. The product was used without further purification.

後処理

  1. temperatureheated
  2. temperatureto reflux for 48 h
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-0cbde3c2a82a4113837f2babf03f86ec
出典データセット
uspto-grants-2005_02
特許番号
US06855715B1

関連ノート

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