(2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane → (2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane

HRID 2396145ノート

反応式

HRID 2396145 の反応式
C(OC([NH:8][C@H:9]([C@@H:17]([OH:22])[CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][C@H:9]([C@@H:17]([OH:22])[CH2:18][CH:19]([CH3:20])[CH3:21])[CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

参加物

3

反応物 1

HCID 57261833(2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane

生成物 1

HCID 22861533(2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane収率 100.4%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of (2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane (120 mg) in trifluoroacetic acid (3 ml) was stirred at 0° C. for 30 minutes. After evaporation of the solvent, the residue was dissolved in ethyl acetate (10 ml). The solution was washed with saturated sodium bicarbonate solution and saturated sodium chloride solution, dried over magnesium sulfate, and evaporated in vacuo to give (2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane (82 mg) as an oil. Rf: 0.30 (chloroform: methanol: acetic acid, 16:1:1, V/V)

後処理

  1. customAfter evaporation of the solvent
  2. dissolutionthe residue was dissolved in ethyl acetate (10 ml)
  3. washThe solution was washed with saturated sodium bicarbonate solution and saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-510f04a479724d008b74098e86518c92
出典データセット
uspto-grants-1996_02
特許番号
US05491132

反応ノート

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