Triethylamine → benzyl N-pyridin-3-ylcarbamate
反応式
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.Cl[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]>ClCCl>[C:16]([NH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]参加物
5
実験手順
To a solution of 3-aminopyridine (10 g, 0.106 mol) and triethyl amine (16.3 mL, 0.117 mol) in dichloromethane (100 mL) at 0° C., was added benzyl chloroformate (15.2 mL, 0.106 mol) slowly. The reaction mixture was stirred overnight and was washed with water, saturated NaHCO3, dried over MgSO4, and evaporated. The residue was purified on a silica gel column to give the product (9.51 g)
後処理
- washwas washed with water, saturated NaHCO3
- dry with materialdried over MgSO4
- customevaporated
- customThe residue was purified on a silica gel column
出典と根拠
- ORDレコード
- ord-21302e956b554cc7913f7c0fb9fb4cf0
- 出典データセット
- uspto-grants-1996_02
- 特許番号
- US05492916
反応ノート
読み込み中…