3-Bromo-1-propanol → 3-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol

HRID 2396508

反応式

HRID 2396508 の反応式
[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][C:9](=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:21][CH2:22][CH2:23][OH:24]>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:10]=[C:9]([O:19][CH2:21][CH2:22][CH2:23][OH:24])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 123083-Bromo-1-propanolHCID 38462014,6-Diphenyl-2-pyridone

生成物 1

HCID 189872833-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol

試薬・触媒・溶媒 2

HCID 178418647HCID 178418647、化合物触媒HCID 1140Toluene溶媒

実験手順

The procedure in Example 4 is followed but using 4,6-diphenyl-2-pyridone (15 g), freshly distilled 3-bromo-1-propanol (16.5 cc), silver carbonate (8.4 g) and toluene (600 cc). The reaction mixture is refluxed for 144 hours. The product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3). (white solid; m.p.=94° C.)

後処理

  1. temperatureThe reaction mixture is refluxed for 144 hours
  2. customThe product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3)

出典と根拠

ORDレコード
ord-3ba0fce85e394da99a4bd7067d820af7
出典データセット
uspto-grants-1996_02
特許番号
US05492915

関連ノート

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