2',3',4'-Trichloroacetophenone → 1-(2,3,4-Trichlorophenyl)ethan-1-ol

HRID 2396874ノート

反応式

HRID 2396874 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:12])[CH3:11].[BH4-].[Na+]>CO>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[CH:10]([OH:12])[CH3:11]

参加物

4

反応物 2

HCID 261322',3',4'-TrichloroacetophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 167691051-(2,3,4-Trichlorophenyl)ethan-1-ol収率 99.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
25 °C

実験手順

In methanol (284 ml) is suspended 2',3',4'-trichloroacetophenone (94.7 g), and thereto is added sodium borohydride (7.6 g) at 15° C.-25° C. The mixture is stirred at 25° C. for two hours, and evaporated to remove the methanol. To the residue is added 2N hydrochloric acid (110 ml), and the mixture is extracted with ethyl acetate. The organic layer is washed with water, dried, and evaporated to remove the solvent to give crude 1-(2,3,4-trichlorophenyl)ethanol (95 g).

後処理

  1. customevaporated
  2. customto remove the methanol
  3. additionTo the residue is added 2N hydrochloric acid (110 ml)
  4. extractionthe mixture is extracted with ethyl acetate
  5. washThe organic layer is washed with water
  6. customdried
  7. customevaporated
  8. customto remove the solvent

出典と根拠

ORDレコード
ord-308a49edd35b4baa80ce56694a1619f2
出典データセット
uspto-grants-1996_02
特許番号
US05495012

反応ノート

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