Benzene → Isobutyl 3,7,11-trimethyldodeca-2,4-dienoate

HRID 2397300ノート

反応式

HRID 2397300 の反応式
[CH3:1][C:2]([CH:7]=[CH:8][CH2:9][CH:10]([CH3:17])[CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:3][C:4]([OH:6])=[O:5].[C:18](Cl)(=O)C(Cl)=O.[CH:24]1[CH:29]=[CH:28]C=CC=1>>[CH3:1][C:2]([CH:7]=[CH:8][CH2:9][CH:10]([CH3:17])[CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:3][C:4]([O:6][CH2:18][CH:29]([CH3:28])[CH3:24])=[O:5]

参加物

4

反応物 3

HCID 241BenzeneHCID 65578Oxalyl chlorideHCID 1037233,7,11-Trimethyldodeca-2,4-dienoic acid

生成物 1

HCID 53880681Isobutyl 3,7,11-trimethyldodeca-2,4-dienoate

実験手順

To a solution of 4.15 g. of 3,7,11-trimethyldodeca-2,4-dienoic acid in 100 ml. of dry benzene, under nitrogen, is added 5.1 ml. of oxalyl chloride. After 2 hours, solvent is removed under reduced pressure and 100 ml. of fresh dry benzene and 6.4 ml. of dry isobutyl alcohol is added. The reaction mixture is concentrated and the concentrate is stirred over 20 g. of activated alumina in pentane for 0.5 hr. and filtered. The filtrate is washed, dried and evaporated under reduced pressure to give isobutyl 3,7,11-trimethyldodeca-2,4-dienoate which can be purified by distillation.

後処理

  1. customsolvent is removed under reduced pressure and 100 ml
  2. additionof dry isobutyl alcohol is added
  3. concentrationThe reaction mixture is concentrated
  4. waitof activated alumina in pentane for 0.5 hr
  5. filtrationand filtered
  6. washThe filtrate is washed
  7. customdried
  8. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-7da2645935904472b95f553be7d893d1
出典データセット
uspto-grants-1977_05
特許番号
US04021461

反応ノート

読み込み中…