Propionic anhydride → 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH2:12])[C:6]([NH2:13])=[N:5]2.[C:14](OC(=O)CC)(=O)[CH2:15][CH3:16]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]1[NH:12][C:14]([CH2:15][CH3:16])=[N:13][C:6]1=[N:5]2参加物
4
実験手順
Four parts of 6-chloro-2,3-diaminoquinoxaline was combined with 3 parts of propionic anhydride in 2 parts of tetrahydrofuran. The mixture was heated for three hours during which time a thick slurry formed. The solid was collected from the hot mixture by filtration and washed twice with two parts of tetrahydrofuran. The gray solid was air-dried to give four parts of 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline, m.p. 298°-300°.
後処理
- temperatureThe mixture was heated for three hours during which time a thick slurry
- customformed
- filtrationThe solid was collected from the hot mixture by filtration
- washwashed twice with two parts of tetrahydrofuran
- customThe gray solid was air-dried
出典と根拠
- ORDレコード
- ord-9e35a6b9f5a54dd29f6ad807ad3dde7b
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04022777
反応ノート
読み込み中…