Benzoyl chloride, 3,4,5-trimethoxy- → 6-(3,4,5-Trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline

HRID 2397937

反応式

HRID 2397937 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([CH3:12])[CH2:6][CH2:5]2.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25])[C:18](Cl)=[O:19]>>[CH3:27][O:26][C:22]1[CH:21]=[C:17]([CH:16]=[C:15]([O:14][CH3:13])[C:23]=1[O:24][CH3:25])[C:18]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([CH3:12])[CH2:6][CH2:5]2)=[O:19]

参加物

3

反応物 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 214367412-Methyl-1,2,3,4-tetrahydroisoquinolin-6-amine

生成物 1

HCID 2165936-(3,4,5-Trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline

実験手順

6-Amino-2-methyl-1,2,3,4-tetrahydroisoquinoline was reacted with 3,4,5-trimethoxybenzoyl chloride as in Example 16 to yield 6-(3,4,5-trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline. It was recovered as the HCl salt; m.p. 233.5°-235° C. after purification in methanol.

出典と根拠

ORDレコード
ord-bec9069431bb45fc91c40e6826400640
出典データセット
uspto-grants-1977_05
特許番号
US04022900

関連ノート

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