Sodium Carbonate → 17beta-Hydroxy-1alpha-methyl-4-androsten-19-one

HRID 2397979ノート

反応式

HRID 2397979 の反応式
C(O)(=O)CC.[OH:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:24]([CH2:25][CH2:26][C@:8]12[CH3:9])[C@:21]1([CH:22]=[O:23])[C:16](=[CH:17][CH2:18][CH2:19][C@@H:20]1[CH3:27])[CH2:15][CH2:14]3.C(=O)([O-])[O-].[Na+].[Na+]>CO>[OH:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:24]([CH2:25][CH2:26][C@:8]12[CH3:9])[C@:21]1([CH:22]=[O:23])[C:16](=[CH:17][CH2:18][CH2:19][C@@H:20]1[CH3:27])[CH2:15][CH2:14]3

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 8673473517beta-Hydroxy-1alpha-methyl-4-androsten-19-one propionate

生成物 1

HCID 8673473617beta-Hydroxy-1alpha-methyl-4-androsten-19-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 17β-hydroxy-1α-methyl-4-androsten-19-one propionate and sodium carbonate in aqueous methanol is refluxed under nitrogen for approximately 2 hours and poured onto water. The oil which forms is extracted with ether. The ether extract is washed with water, dried over sodium sulfate, and concentrated under reduced pressure. The residue which remains is eluted from silica gel with benzene and crystallized from hexane to yield 17β-hydroxy-1α-methyl-4-androsten-19-one.

後処理

  1. additionpoured onto water
  2. extractionThe oil which forms is extracted with ether
  3. extractionThe ether extract
  4. washis washed with water
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated under reduced pressure
  7. washThe residue which remains is eluted from silica gel with benzene
  8. customcrystallized from hexane

出典と根拠

ORDレコード
ord-b1f3193195c2446bae13c3f96ddee847
出典データセット
uspto-grants-1977_05
特許番号
US04022769

反応ノート

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