Thionyl Chloride → HCID 21434993、化合物
反応式
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:14](O)=[O:15])=[CH:8][N:9]2[CH2:12][CH3:13])=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:14]([Cl:20])=[O:15])=[CH:8][N:9]2[CH2:12][CH3:13])=[CH:4][CH:3]=1参加物
4
実験手順
7-Chloro-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (29.5 g) and thionyl chloride (18 ml) in dry toluene (900 ml) were stirred and heated under reflux for 1 hour. The solution was cooled and the solid that separated was collected. It had m.p. 186.5°-188.5° (98%).
後処理
- temperatureheated
- temperatureunder reflux for 1 hour
- temperatureThe solution was cooled
- customthe solid that separated
- customwas collected
出典と根拠
- ORDレコード
- ord-d9cdfc69b04243d0bb418d24449f8ea9
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04024255
反応ノート
読み込み中…