Hydrochloric Acid → 4,6-Dibromo-5-hydroxypyridine-2-carboxylic acid
反応式
[OH-].[Na+].C[O:4][C:5]([C:7]1[CH:12]=[C:11]([Br:13])[C:10]([OH:14])=[C:9]([Br:15])[N:8]=1)=[O:6].Cl>O>[Br:13][C:11]1[C:10]([OH:14])=[C:9]([Br:15])[N:8]=[C:7]([C:5]([OH:6])=[O:4])[CH:12]=1参加物
5
実験手順
A solution of 0.5 g sodium hydroxide in 15 ml of water was added to 2 g of 4,6-dibromo-5-hydroxy-2-pyridine-carboxylic acid methyl ester and refluxed for 2 hours. The product was isolated, by cooling and acidifying with concentrated hydrochloric acid, in 53% yield; m.p. 195° -197° C.
後処理
- temperaturerefluxed for 2 hours
- customThe product was isolated
- temperatureby cooling
出典と根拠
- ORDレコード
- ord-b806ab5a3fed4ab3871c1a73a4419a67
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04025333
反応ノート
読み込み中…