Acetic Acid → 5-Benzoxazoleacetic acid, 2-phenyl-
反応式
OC([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10][C:9]=2[CH:19]=1)C#N.C.[C:21]([OH:24])(=[O:23])[CH3:22]>[Pd]>[C:13]1([C:11]2[O:12][C:8]3[CH:7]=[CH:6][C:5]([CH2:22][C:21]([OH:24])=[O:23])=[CH:19][C:9]=3[N:10]=2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1参加物
5
実験手順
A solution of α-hydroxy-2-phenyl-5-benzoxazolyl-acetonitrile (2 g.) in acetic acid (30 ml.) containing palladium or charcoal was hydrogenated for 4 hours. The catalyst was filtered off and the solution was evaporated to dryness. The residue was recrystallised to give pure 2-phenyl-5-benzoxazolylacetic acid m.p. 175° C.
後処理
- filtrationThe catalyst was filtered off
- customthe solution was evaporated to dryness
- customThe residue was recrystallised
出典と根拠
- ORDレコード
- ord-ace5b03aa5ab4d35906bed6526170fa3
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04025636
反応ノート
読み込み中…