2-Fluoro-5-methylphenyl isocyanate → N-(4-bromo-2-ethylphenyl)-N'-(2-fluoro-5-methylphenyl)urea
反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH2:9][CH3:10])[CH:3]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=1[N:19]=[C:20]=[O:21]>ClCCl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:20]([NH:19][C:13]2[CH:14]=[C:15]([CH3:18])[CH:16]=[CH:17][C:12]=2[F:11])=[O:21])=[C:4]([CH2:9][CH3:10])[CH:3]=1参加物
4
実験手順
A solution of 4-bromo-2-ethylaniline (200 mg) in dichloromethane (10 mL) was treated with 1-fluoro-2-isocyanato-4-methylbenzene (151 mg), stirred at room temperature overnight, diluted with hexanes, and filtered. The filter cake provided 227 mg of the desired product. MS (ESI(+)) m/e 351,353 (M+H)+.
後処理
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-2b6b93845cc1458e9aa075848bbde5c7
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642776B2
反応ノート
読み込み中…