Hydrogen Bromide → gamma-Morpholinobutyric acid hydrobromide

HRID 2398885ノート

反応式

HRID 2398885 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][C:10]([O:12]C)=[O:11])[CH2:3][CH2:2]1.[BrH:14]>O>[BrH:14].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 44858Methyl 4-morpholinobutanoate

生成物 1

HCID 68121683gamma-Morpholinobutyric acid hydrobromide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

15 g. (0.052 mole) of Methyl γ-morpholinobutyrate (Cruickshank and Sheehan, J. Am. Chem. Soc. 83, 2891 (1961) was dissolved in a mixture of 45 ml. of 47% hydrobromic acid and 45 ml. of water and heated for 16 hours at reflux. The solution was taken to dryness under reduced pressure, and the solid which formed was triturated with acetone. The material was filtered and crystallized from 60 ml. of acetic acid to give 12.4 g. (95%) of product as colorless crystals, m.p. 151°-152.5°. The infrared and nmr spectra are consistent with the proposed structure.

後処理

  1. dissolution83, 2891 (1961) was dissolved in a mixture of 45 ml
  2. temperatureat reflux
  3. customthe solid which formed
  4. customwas triturated with acetone
  5. filtrationThe material was filtered
  6. customcrystallized from 60 ml
  7. customof acetic acid to give 12.4 g

出典と根拠

ORDレコード
ord-2bfa2a129a5a4272bac73557281a64ed
出典データセット
uspto-grants-1977_05
特許番号
US04025630

反応ノート

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