Nitric Acid → HCID 21432601、化合物

HRID 2399042ノート

反応式

HRID 2399042 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[N+:15]([O-])([OH:17])=[O:16].[OH-].[NH4+]>>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 14923Ammonium HydroxideHCID 780542-(4'-Chlorobenzyl)pyridine

生成物 1

HCID 21432601HCID 21432601、化合物

実験手順

99 G. (0.487 mol) of 2-(p-chlorobenzyl)pyridine was added to 500 ml. of fuming nitric acid cooled to 10 ° while maintaining the temperature at <10° for 2 hours. The resulting mixture was poured into 800 ml. of ice, neutralized with ammonium hydroxide and allowed to stand overnight at room temperature. The resulting solid was collected, washed with water and air dried to give 2-(4-chloro-3-nitrobenzyl)pyridine as off-white prisms, m. 58°-60° C. (aq. ethanol).

後処理

  1. temperaturewhile maintaining the temperature at <10° for 2 hours
  2. additionThe resulting mixture was poured into 800 ml
  3. customThe resulting solid was collected
  4. washwashed with water and air
  5. customdried

出典と根拠

ORDレコード
ord-d013ac3343f44494b03dee9870966de1
出典データセット
uspto-grants-1977_05
特許番号
US04026936

反応ノート

読み込み中…