Benzene, (2-chloroethoxy)- → Phenoxyethyl-norfentanyl

HRID 2399172

反応式

HRID 2399172 の反応式
[C:1]1([N:7]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:8](=[O:11])[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:18]([CH2:25][CH2:26]Cl)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[O:18]([CH2:25][CH2:26][N:15]1[CH2:14][CH2:13][CH:12]([N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[O:11])[CH2:9][CH3:10])[CH2:17][CH2:16]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

3

反応物 2

HCID 12156Benzene, (2-chloroethoxy)-HCID 2593814-(N-Propionylaniline)piperidine

生成物 1

HCID 54005394Phenoxyethyl-norfentanyl収率 98.6%

実験手順

By condensing 14.7 g 4-(N'-phenyl-N'-propionylamino)-piperidine and 19.9 g phenoxyethyl chloride, they are obtained after 24 hours reflux 22 g of the title product which after recrystallization from hot cyclohexane gives a first crop weighing 13.5 g. The pure compound melts at 100°-102°. It is soluble in hydrochloric acid. The solution after distillation leads to the recovery of the hydrochloride. The hydrochloride is soluble in water.

後処理

  1. customare obtained after 24 hours

出典と根拠

ORDレコード
ord-06dc97e744cf48a0a7842a8396006747
出典データセット
uspto-grants-1977_05
特許番号
US04027028

関連ノート

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