Phenol → Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate

HRID 2399491

反応式

HRID 2399491 の反応式
C([O-])([O-])=O.[K+].[K+].CC(C)=O.C1(O)C=CC=CC=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH:24]=[C:25]([O:28][CH3:29])[C:26]=1[OH:27])[CH:22]=[O:23].Br[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH2:37][C:38]([O:40][CH3:41])=[O:39]>>[Cl:18][C:19]1[CH:20]=[C:21]([CH2:22][OH:23])[CH:24]=[C:25]([O:28][CH3:29])[C:26]=1[O:27][CH:37]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:31]=1)[C:38]([O:40][CH3:41])=[O:39]

参加物

5

反応物 4

HCID 996PhenolHCID 296223-Chloro-4-hydroxy-5-methoxybenzaldehydeHCID 8063364Methyl 2-(2-bromophenyl)acetateHCID 86600397Acetone potassium carbonate

生成物 1

HCID 19385663Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate収率 64.6%

実験手順

Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.50 g (2.62 mmol) of 3-chloro-4-hydroxy-5-methoxybenzaldehyde was alkylated with 0.668 g (2.92 mmol) of methyl 2-bromophenylacetate to afford 0.570 g (64%) of the title compound.

出典と根拠

ORDレコード
ord-6db11a8b3b2b471294602241b46af3cf
出典データセット
uspto-grants-1995_09
特許番号
US05449682

関連ノート

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