Pyrrole-2-carboxaldehyde → Methyl 3-(1H-pyrrol-2-yl)propanoate
反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[C:8]([CH:12]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:10][CH3:11])=[O:9]>C1C=CC=CC=1>[CH3:11][O:10][C:8]([CH2:12][CH2:6][C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)=[O:9]参加物
4
実験手順
The 2-(2-methoxycarbonylethyl)pyrrole is prepared as follows: A solution of pyrrole-2-carboxaldehyde (3.9 g, 41 mmol) and (carbomethoxymethylene)triphenylphosphorane (14 g, 42 mmol) in 160 mL of dry benzene is heated at reflux for 18 hours under a nitrogen atmosphere. After cooling, the reaction mixture is concentrated under vacuum and the resulting oil is purified by silica gel column chromatography, eluting with a mixture of ethyl acetate and hexane (1:9) to give 5.11 g of a mixture of cis- and trans-methyl 2-(2-pyrrolyl)acrylate.
後処理
- temperatureat reflux for 18 hours under a nitrogen atmosphere
- temperatureAfter cooling
- concentrationthe reaction mixture is concentrated under vacuum
- customthe resulting oil is purified by silica gel column chromatography
- washeluting with a mixture of ethyl acetate and hexane (1:9)
出典と根拠
- ORDレコード
- ord-0298f18eedcc49d5af009c9224d0cc87
- 出典データセット
- uspto-grants-1995_09
- 特許番号
- US05451663
反応ノート
読み込み中…