Dodecanoyl chloride → HCID 9865002、化合物

HRID 2399912ノート

反応式

HRID 2399912 の反応式
[OH:1][CH2:2][C:3]1[CH:7]([CH3:8])[O:6][C:5](=[O:9])[C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:16](Cl)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].C(N(CC)CC)C.CN(C1C=CC=CN=1)C>C1COCC1>[C:16]([O:1][CH2:2][C:3]1[CH:7]([CH3:8])[O:6][C:5](=[O:9])[C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:28])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

参加物

6

反応物 4

HCID 8166Dodecanoyl chlorideHCID 8471TriethylamineHCID 218852-DimethylaminopyridineHCID 15295494HCID 15295494、化合物2 回

生成物 1

HCID 9865002HCID 9865002、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-Hydroxymethyl-5-methyl-3-phenyl-2(5H)-furanone (Compound 7), (73 mg, 0.36 mmol), lauroyl chloride (117 mg, 0.54 mmol), triethylamine (47 mg, 0.47 mmol) and dimethylaminopyridine (1 mg, 0.01 mmol) were stirred in anhydrous THF (2 mL) at ambient temperature under argon for 2 hours. The crude reaction mixture was concentrated, the organics were extracted into diethyl ether and solids were filtered off. The ether was removed by rotary evaporator and the resulting oil was purified by flash chromatography on silica to give the title compound.

後処理

  1. customThe crude reaction mixture
  2. concentrationwas concentrated
  3. extractionthe organics were extracted into diethyl ether and solids
  4. filtrationwere filtered off
  5. customThe ether was removed by rotary evaporator
  6. customthe resulting oil was purified by flash chromatography on silica

出典と根拠

ORDレコード
ord-f6331677e6984201a1a4be3cf385bdea
出典データセット
uspto-grants-1995_09
特許番号
US05451686

反応ノート

読み込み中…