1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine → 3-Ethylaminomethyl-3-hydroxypyrrolidine
反応式
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][NH:15][CH2:16][CH3:17])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:16]([NH:15][CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]参加物
4
実験手順
10 g (42.7 mmol) of 1-benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine in 60 ml of methanol are hydrogenated using 2 g of palladium/active carbon (10%) at 92°C. and 107 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
後処理
- customat 92°C.
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-77d18c2b5e734b77b792392d7ab8b6ef
- 出典データセット
- uspto-grants-1995_09
- 特許番号
- US05453422
反応ノート
読み込み中…