Methyl alpha-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate → Methyl [6-methyl-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate

HRID 2400122ノート

反応式

HRID 2400122 の反応式
[CH3:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:11]=2)[C:3]=1[CH2:22][C:23]([O:25][CH3:26])=[O:24]>CO.C(N(CC)CC)C.[Pd]>[CH3:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:11]=2)[C:3]=1[CH2:22][C:23]([O:25][CH3:26])=[O:24]

参加物

4

反応物 1

HCID 19044661Methyl alpha-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate

生成物 1

HCID 19044665Methyl [6-methyl-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 22728368Triethylamine methanol溶媒

実験手順

Methyl α-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate is dissolved in methanol/triethylamine (50 ml/10 ml) and hydrogenated over Pd on charcoal (0.2 g). The reaction mixture is evaporated. Addition of potassium carbonate, ether extraction and chromatography on silica gel gives pure methyl α-[6-methyl-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate.

後処理

  1. customThe reaction mixture is evaporated
  2. additionAddition of potassium carbonate, ether extraction and chromatography on silica gel

出典と根拠

ORDレコード
ord-8c5651326c36428e8fcef44f6cfc5f83
出典データセット
uspto-grants-1995_09
特許番号
US05453427

反応ノート

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