Water → HCID 178492676、化合物

HRID 2400139

反応式

HRID 2400139 の反応式
[F:1][C:2]1[C:3]([NH2:9])=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[C:15](Cl)=[O:16].O>N1C=CC=CC=1>[F:1][C:2]1[C:3]([NH:9][C:15](=[O:16])[C:14]2[CH:13]=[C:12]([O:11][CH3:10])[C:20]([O:21][CH3:22])=[C:19]([O:23][CH3:24])[CH:18]=2)=[N:4][C:5](=[O:8])[NH:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 178509021HCID 178509021、化合物

生成物 1

HCID 178492676HCID 178492676、化合物収率 90.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

12.9 g of 5-fluorocytosine was suspended in 78 ml of pyridine, followed by addition of 23.1 g of 3,4,5-trimethoxybenzoyl chloride and stirring at 100° C. for 5 hours. The reaction mixture was cooled down to room temperature and then poured into 310 ml of water at room temperature over a period of 20 minutes. The precipitated crystals were collected by filtration to obtain 29.2 g (90.4%) of 5-fluro-N4 -(3,4,5-trimethoxybenzoyl)cytosine.

後処理

  1. temperatureThe reaction mixture was cooled down to room temperature
  2. filtrationThe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-17bf57979d154eaf9743da8f3f9d9e25
出典データセット
uspto-grants-1995_09
特許番号
US05453497

関連ノート

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